Comparing the level of plasma Malone dialdehide (MDA) in LD contraceptive pill and condom users

Document Type : Original Quantitative and Qualitative Research Paper

Authors

1 MSc in Midwifery, Nursing and Midwifery School, Shahid Beheshti University of Medical Science, Tehran, Iran

2 Instructor in Midwifery, Department of Midwifery, Nursing and Midwifery School, Shahid Beheshti University of Medical Science, Tehran, Iran

3 Assistant professor in Biochemestry, Department of Reproductive Biology, Shiraz University of Medical Sciences, Shiraz, Iran

4 Assistant professor in Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran

Abstract

Background: Among the non-surgical methods of preventing conception, taking oral contraceptive pills is the most common way. Some of the studies have shown that contraceptive pills due to containing estrogen and progesterone cause lipid peroxidation and as a consequence increase the level of oxidative stress.
Aim: To compare the level of plasma Malone dialdehide in LD contraceptive pill and condom users.
Method: In this study, 80 women who were taking LD contraceptive pills to prevent pregnancy and 38 women who used condom were selected from clients who referred to Shiraz health centers (Mehr& Samenolaeme) Plasma Malon dialdehyde was measured by thiobarbituric acid method. Data were analyzed with SPSS Software version 17, using Mann-Whitney and t-test.
Results: The mean level of plasma Malon dialdehyde in contraceptive pill users was (4/19±0/836 Ng/ml) and in condom users was (3/32±0/758 Ng/ml). In order to evaluate the differences between two groups t-test showed statistically significant difference in the level of plasma Malon dialdehyde in contraceptive pill and condom users.
Conclusion: This study showed that oral contraceptive pills increase plasma Malone dialdehide.  

Keywords

References

  1. Groote D, Hauteriveb S, Pintiauxb A, Balteaub B,Gerdayb C, Claesena J (2009). Effects of Oral Contraception with Ethinylestradiol and Drospirenone on Oxidative Stress in Women 18–35 Years Old. Contraception .80, 187–93.
  2. Jackson M J, O'Farrell S (1993). Free Radicals and Muscle Damage. Br Med Bull. 49( 3) , 630-41.
  3. Rahimi R, Nikfar S, Larijani B, Abdollahi M (2005). A Review on the Role of Antioxidants in the Management of Diabetes and Its Complications. BIOPHA. 59 . 365-73.
  4. Kumar S, Lata K, Mukhopadhyay S, Mukherjeeal T (2010). Role of Estrogen Receptors in Pro-Oxidative and Anti-Oxidative Actions of Estrogens .BBA.118  (2). 1-43.
  5. Bell H.K, Bloomer R (2010). Impact of Serum Estradiol on Postprandial Lipemia, Oxidative Stress, and Inflammation Across a Single Menstrual Cycle. J Gen Intern Med. 7(2) 166-78.
  6. Cunningham  F, Leveno K, Bloom S, Hauth J, Gilstrap L, Wenstrom K (2010). Williams Obstetrics. 23 th edition. Volume 2. New York, MC Graw Hill.
  7. Spiroff L, Feritis M (2005). Clinical Gynecology Endocrinology& Iinfertility. 7th ed. USA, Lippincott Williams and Wilkins.
  8. Saha A, de AU, Sengupta C. Ethinyl Estradiol; Its Interaction on Blood-Lipid. Ind J Exp Biol. 2000;38: 906-11.
  9. Ling S, Komesaroff P, Sudhir K. Cellular Mechanisms Underlying the Cardiovascular Actions of Estrogens. Clin Sc. 2006;111:107-18
  10. Faddah L, Rehany M, Abdel-Hamid N, Bakeet A (2005). Oxidative Stress, Lipid Profile and Liver Functions in Average Egyptian Long Term Depo Medroxy Progesterone Acetate (Dmpa) Users. Molecules.  10, 1145-52.
  11. Palan p, Strube F, Letko J, Sadikovic A, Mikhail M  (2010). Effects of Oral, Vaginal, and Transdermal Hormonal Contraception on Serum Levels of Coenzyme Q10, Vitamin E, and Total Antioxidant. Obstet Gynecol Int. 2010, 1-4.
  12. Palan P, Magneson A, Castillo M, Dunne J, Mikhail M (2006). Effects of Menstrual Cycle and Oral Contraceptive Use on Serum Levels of Lipid-Soluble Antioxidants. Am J Obstet Gynecol. 194, 35–8.
  13. Akinloye O, Oyubiyi S, Oguntibeju O, Arowojolu A (2010). Non Enzymatic Antioxidant Status of Women Using Four Different Methods of Contraception. Pak j Med Sci. 26(2) 374-9.
  14. Tsutamoto T, Wada A, Matsumoto T, Maeda K, Mabuchi N, Hayashi M, et al (2001). Relationship Between Tumor Necrosis Factor-Alpha Production and Oxidative Stress in the Failing Hearts of Patients with Dilated Cardiomyopathy. JACC. 37(8) 2086-92.
  15. Bhutia R, Upadhyay B, Maneesh M (2006). Association of Plasma Lenel of Thiobarbituric Acid Reactive Substances with Extent of Hepatocellular Injury in Preterm Infants with Cholestatic Jaundice. Indian J Clin Biochem. 21 (2) 39-41.
  16. Family planning and health office (1388). Instruction of Family Planning in Republic Islamic of Iran, Ministry of Health. Tehran. Iran.(Persian)
  17. Alavi majd H, Sample Volume in Medical Research(1385). Medical university of Shahid Beheshti  Publication.58-61S.(Persian)
  18. Ciavati M, Blac aggrehe D, Renaud S (1989). Hormonal Contraceptive Increases Plasma Lipid Peroxides in Female Rats. Relationship to platelet aggregation and lipid biosynthesis. Arterioscler Thromb Vasc Biol. 9:84-9.
  19. Subakir S.B, Setiadi E, Affandi B, Pringgoutomo S, Freisleben H (2000). Benefits of Vitamin E Supplementation to Norplant Users in Vitro And in Vivo Studies. Toxicology. 148(4) , 173–8.
  20. Behall KM, Moser PB, Kelsay JL, Prather ES. The Effect of Kind of Carbohydrate in the Diet and the Use of Oral Contraception on Metabolism of Young Women. Am J Clin Nutr. 1980;33:825–31.
  21. Ciavati M, Blac aggrehe D, Renaud S (1989). Hormonal Contraceptive Increases Plasma Lipid Peroxides in Female Rats. Relationship to platelet aggregation and lipid biosynthesis hormonal contraceptive increases plasma lipid peroxides in female rats. Arterioscler Thromb Vasc Biol. 9:84-9.
  22. Vincent H, Bourguignonb C, Weltman A, Vincenta K, Barrette E, Innesb K (2009). Effects of Antioxidant Supplementation on Insulin Sensitivity, Endothelial Adhesion Molecules, and Oxidative Stress in Normal-Weight and Overweight Young Adults. Metabolism. 58, 224- 62.
  23. Pincemail J, Vanbelle S, Gaspard U, Collette G, Haleng J, Cheramy-Bien J et al (2007). Effect of Different Contraceptive Methods on the Oxidative Stress Status in Women Aged 40–48 Years from the Elan Study in the Province of Lie`Ge, Belgium. Hum Reprod.22(8) 2335–43.
  24. Mastaloudis A,  Jason y, Morrow D, Hopkins D,  Devaraj S, Traber M (2004). Antioxidant Supplementation Prevents Exercise Induced Lipid Peroxdation Inflammation 1in Ultramarathon Runners . . Free Radic Biol Med. 36( 10).1329 –41.
Evidence Based Care
Volume 2, Issue 3 - Serial Number 3
شماره پیاپی چهارم
October 2012
Pages 33-39

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