An Evidence Based Review on Oriental Medicine for the Treatment of Herpes Simplex Infections and Their Availability in Iran

Authors

1 Assistant Professor of Complementary Medicine, Department of Chinese and Complementary Medicine, School of traditional and Complementary medicine, Mashhad University of Medical Sciences, Mashhad, Iran Addiction Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Associate professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Assistant Professor of Complementary Medicine, Department of Chinese and Complementary Medicine, School of traditional and Complementary medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Assistant Professor of Traditional Medicine, Department of Traditional Medicine, School of Traditional Iranian Medicine, Tehran University of Medical Sciences, Tehran, Iran

5 PhD candidate in Crop Ecology, Department of Agronomy, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran

6 Gynecology resident, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

7 Associate professor of Cardiology, Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

8 Medical student, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

9 Assistant professor, Department of Pharmacognosy & Pharmaceutics, Institute of Medicinal Plants, ACECR, Karaj, Iran

Abstract

Background: Herpes Simplex Virus (HSV) infections are very common in Iran and worldwide and the risk for resistance to anti-herpetic drugs has increased recently. Alternative antiherpetic agents seem necessary to control and reduce the emergence of -resistant strains. Oriental medicine suggests some herbal options for the treatment of herpes lesions.
Aim: This study reviews some of the common herbal treatments in oriental medicine for herpes and their availability in Iran.
Methods: In this narrative review, information on in vitro and in vivo studies and clinical trials was searched via international databases including PubMed and SCOPUS, using herpes, herb, Oriental medicine, Chinese medicine and the names of herbs as keywords, which resulted in 45 related articles; of these, 38 entered this review. The inclusion criteria were the in vitro and in vivo studies, randomized controlled trials and reviews with acceptable levels of evidence. Information regarding those herbs in traditional Iranian medicine, their availability in Iran, and the available pharmaceutical products in this country were investigated through Persian references.
Results: Among herbs suggested by Oriental herbal medicine for the treatment of herpes lesions, Melia azedarach, Aloe barbadensis, Rheum palmatum, Salvia officinalis, Melissa officinalis, Melaleuca alternifolia, Hypericum perforatum, Crataegus pinnatifida, Punica granatum and Rheum palmatum, are backed by acceptable scientific evidence, and are available in Iran.
Conclusion: Considering the evidence and availability of many of Oriental herbal medicines for herpes in Iran, they can be utilized for treatment and research purposes.

Keywords

Main Subjects


  1. Xu F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, et al. Trends in Herpes Simplex Virus Type 1 and Type 2 Seroprevalence in the United States. JAMA. 2006; 296(8): 964-73.
  2. Ziyaeyan M, Japoni A, Roostaee MH, Salehi S and Soleimanjahi H. A Serological Survey of Herpes Simplex Virus Type 1 and 2 Immunity in Pregnant Women at Labor Stage in Tehran, Iran. Pak. J. Biol. Sci. 2007; 10(1): 148-51.
  3. Ziyaeyan M,Alborzi A, Japoni A, Kadivar M, Davarpanah MA, Pourabbas B, et al. Frequency of Ayclovir-Resistant Herpes Simplex Viruses Isolated from the General Immunocompetent Population and Patients with Acquired Immunodeficiency Syndrome. Int. J. Dermatol. 2007; 46(12): 1263-6.
  4. Stranska R, Schuurman R, Nienhuis E, Goedegebuure IW, Polman M, Weel JF, et al. Survey of Acyclovir-Resistant Herpes Simplex Virus in the Netherlands: Prevalence and Characterization. J. Clin. Virol. 2005; 32(1): 7-18.
  5. Kurokawa M, Nagasaka K, Hirabayashi T, Uyama S, Sato H, Kageyama T, et al. Efficacy of Traditional Herbal Medicines in Combination with Acyclovir Against Herpes Simplex Virus Type 1 Infection In vitro and In vivo. Antiviral Res. 1995; 27(1-2): 19-37.
  6. Bensky D, Clavey S, Stoger E. Chinese Herbal Medicine Materia Medica, 3rd ed. Eastland Press. Seattle, USA. 2004.
  7. Beijing University of Traditional Chinese Medicine (editor). The Chinese Materia Medica. Academy Press. Beijing. 1998.
  8. Beijing University of Traditional Chinese Medicine (editor). Traditional Chinese Internal Medicine. Academy Press. Beijing. 2000.
  9. Mozaffarian V. A dictionary of Iranian plant names. Farhang Moaser Publisher. Tehran. 2006.
  10. Mahvan A. (Iran Flora Dictionary). Mahnashr. Mashhad. 2002.
  11. Aqili MH. (Makhzanoladvieh). Academy of Medical Sciences. Tehran. (Persian)
  12. Khalighi-Sigaroodi F, Jarvandi S and Taghizadeh M. Therapeutic Indications of Medicinal Plants. Arjmand Press. Tehran. 2010, pp: 146-51. (Persian)
  13. Khoddam R. Pocket guide to Iran generic drugs. 3rd ed. Dibaj. Tehran, Iran. 2007, pp: 1000-34. (Persian)
  14. Alche LE, Ferek GA, Meo M, Coto CE and Maier MS. An Antiviral Meliacarpin from Leaves of Melia Azedarach L. Z. Naturforsch. C 2003; 58(3-4): 215-9.
  15. Alche LE, Barquero AA, Sanjuan NA and Coto CE. An Antiviral Principle Present in a Purified Fraction from Melia Azedarach L. Leaf Aqueous Extract Restrains Herpes Simplex Virus Type 1 Propagation. Phytother. Res. 2002; 16(4): 348-52.
  16. Pifarre MP, Berra A, Coto CE and Alche LE. Therapeutic Action of Meliacine, a Plant-Derived Antiviral, on HSV-Induced Ocular Disease in Mice. Exp. Eye Res. 2002; 75(3): 327-34.
  17. Kim M, Kim SK, Park BN, Lee KH, Min GH, Seoh JY,Park CG,Hwang ES, Cha CY and Kook YH. Antiviral Effects of 28-Deacetylsendanin on Herpes Simplex Virus-1 Replication. Antiviral Res. 1999; 43(2): 103-12.
  18. Barquero AA, Michelini FM and Alche LE. 1-Cinnamoyl-3, 11-Dihydroxymeliacarpin Is a Natural Bioactive Compound with Antiviral and Nuclear Factor-KappaB Modulating Properties. Biochem. Biophys. Res. Commun. 2006; 344(3): 955-62.
  19. Yarnell E, Abascal K, Rountree R. Herbs for Herpes Simplex Infections. J Altern Complement Med. 2009; 15(2):69-74.
  20. Syed TA, Cheema KM, Ashfaq A, Holt AH. Aloe Vera Extract 0.5% in a Hydrophilic Cream Versus Aloe Vera Gel for the Management of Genital Herpes in Males. A Placebo-Controlled, Double-Blind, Comparative Study. J Eur Acad Dermatol Venereol. 1996; 7: 294-5.
  21. Syed TA, Afzal M, Ahmad SA, et al. Management of Genital Herpes in Men with 0.5% Aloe Vera Extract in a Hydrophylic Cream: a Placebo-Controlled Double-Blind Study. J Dermatol Treat. 1997; 8: 99-102.
  22. Vogler BK, Ernst E. Aloe Vera: A Systematic Review of Its Clinical Effectiveness. Br J Gen Pract.1999; 49(447):823-8.
  23. Hsiang CY, Hsieh CL, Wu SL, Lai IL and Ho TY. Inhibitory Effect of Anti-Pyretic and Anti-Inflammatory Herbs on Herpes simplex Virus Replication. Am. J. Chin. Med. 2001; 29(3-4): 459-67.
  24. Wang ZY, Xu B, Song YY, Wang GT, Xu HZ and Wang XF. Inhibition Effects of Rhubarb Ethanol Extract on Herpes Simplex Virus Infection In vivo. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003;17(2):169-73.
  25. Saller R, Buechi S, Meyrat R and Schmidhauser C. Combined Herbal Preparation for Topical Treatment of Herpes Labialis. Forsch. Komplementarmed. Klass. Naturheilkd. 2001; 8(6): 373-82.
  26. Sydiskis RJ, Owen DG, Lohr JL, Rosler KH and Blomster RN. Inactivation of Enveloped Viruses by Anthraquinones Extracted from Plants. Antimicrob. Agents Chemother. 1991; 35(12): 2463-6.
  27. Hohmann J, Zupko I, Redei D, Csanyi M, Falkay G, Mathe I and Janicsak G. Protective Effects of the Aerial Parts of Salvia Officinalis, Melissa Officinalis and Lavandula Angustifolia and their Constituents against Enzyme-Dependent and Enzyme-Independent Lipid Peroxidation. Planta Med. 1999; 65(6): 576-8.
  28. Wolbling RH and Milbradt R. Clinical and Therapeutic Approaches to Herpes Simplex: Introduction of a New Phytotherapeutical Active Substance. Therapiewoche 1984; 34: 1193-200.
  29. Wolbling RH and Leonhardt K. Local Therapy of Herpes Simplex with Dried Extract of Melissa Officinalis. Phytomedicine 1994; 1: 25-31.
  30. Koytchev R, Alken RG and Dundarov S. Balm Mint Extract (Lo-701) for Topical Treatment of Recurring Herpes Labialis. Phytomedicine 1999; 6(4): 225-30.
  31. Vogt M, Tausch I, Wolbling RH, et al. Melissa Extract in Herpes Simplex: A Double-Blind Placebo-Controlled Study. Der Allgemeinartzt 1991; 13: 832-41.
  32. Dimitrova Z, Dimov B, Manolova N, Pancheva S, Ilieva D and Shishkov S. Antiherpes Effect of Melissa Officinalis L. Extracts. Acta Microbiol. Bulg. 1993; 29: 65-72.
  33. Nolkemper S, Reichling J, Stintzing FC, Carle R and Schnitzler P. Antiviral Effect of Aqueous Extracts from Species of the Lamiaceae Family Against Herpes Simplex Virus Type 1 and Type 2 In Vitro. Planta Med. 2006; 72(15): 1378-82.
  34. Schnitzler P, Schuhmacher A, Astani A and Reichling J.  Melissa Officinalis Oil Affects Infectivity of Enveloped Herpes Viruses. Phytomedicine 2008; 15(9): 734-40.
  35. Kuo YC, Kuo YH, Lin YL and Tsai WJ. Yatein from Chamaecyparis Obtusa Suppresses Herpes Simplex Virus Type 1 Replication in HeLa Cells by Interruption the Immediate-Early Gene Expression. Antiviral Res. 2006; 70(3): 112-20.
  36. Kuo YC,Lin LC,Tsai WJ,Chou CJ, Kung SH and Ho YH. Samarangenin B from Limonium Sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis. Antimicrob. Agents Chemother. 2002; 46(9): 2854-64.
  37. Schnitzler P, Schon K and Reichling J. Antiviral Activity of Australian Tea Tree Oil and Eucalyptus Oil against Herpes Simplex Virus in Cell Culture. Pharmazie 2001; 56(4): 343-7.
  38. Naghdi Badi H, Ziai SA, Mirjalili MH, Ahvazi M, Khalighi Sigaroodi F, Habibi Khaniani B and Farahani A.Variation in Quantitative Yield and Hypericin Content of St. John’s wort, Hypericum Perforatum L. J. Medicinal Plants 2004; 3(11): 59-67. (Persian)
  39. Vijayan P, Raghu C, Ashok G, Dhanaraj SA and Suresh B. Antiviral Activity of Medicinal Plants of Nilgiris. Indian J. Med. Res. 2004; 120(1): 24-9.
  40. Sokmen A, Jones BM and Erturk M. Antimicrobial Activity of Extracts from the Cell Cultures of Some Turkish Medicinal Plants. Phytother. Res. 1999; 13(4): 355-7.
  41. Taylor RS, Manandhar NP, Hudson JB and Towers GH. Antiviral Activities of Nepalese Medicinal Plants. J. Ethnopharmacol. 1996; 52(3): 157-63.
  42. Fritz D, Venturi CR, Cargnin S, Schripsema J, Roehe PM, Montanha JA and von Poser GL. Herpes Virus Inhibitory Substances from Hypericum Connatum Lam., a Plant Used in Southern Brazil to Treat Oral Lesions. J. Ethnopharmacol. 2007; 113(3): 517-20
  43. Mukherjee PK and Suresh B. The Evaluation of Wound-Healing Potential of Hypericum Hookerianum Leaf and Stem Extracts. J. Altern. Complement. Med. 2000; 6(1): 61-9.
  44. Shahat AA, Cos P, De Bruyne T, Apers S, Hammouda FM, Ismail SI, Azzam S, Claeys M, Goovaerts E, Pieters L, Vanden Berghe D and Vlietinck AJ. Antiviral and Antioxidant Activity of Flavonoids and Proanthocyanidins from Crataegus Sinaica. Planta Med. 2002; 68(6): 539-41.
  45. Orhan I, Ozcelik B, Kartal M, Ozdeveci B and Duman H. HPLC Quantification of Vitexine-2-o-Rhamnoside and Hyperoside in Three Crataegus Species and Their Antimicrobial Activities. Chromatographia. 2007; 66: 153-7.
  46. Zhang J, Zhan B, Yao X, GAO Y and Shong J. Antiviral Activity of Tannin from the Pericarp of Punica Granatum L. Against Genital Herpes Virus In Vitro. Zhongguo Zhong Yao Za Zhi .1995; 20(9): 556-8.
  47. Mao SP, Cheng KL and Zhou YF. Modulatory Effect of Astragalus Membranaceus on Th1/Th2 Cytokine in Patients with Herpes Simplex Keratitis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004; 24(2): 121-3.
  48. Khalighi-Sigaroodi F, Taghizadeh M and Jarvandi. A guide to herb-drug interactions: including contraindication and side effects of medicinal plants. Jahad Daneshgahi-Shahid Beheshti Press Center. Tehran. 2006, p: 21. (Persian)
  49. Zhang L, Liu Y and Yu Z. Study on the Anti-Herpes Simplex Virus Activity of a Suppository or Ointment form of Astragalus Membranaceus Combined with Interferon Alpha 2b in Human Diploid Cell Culture. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 1998; 12: 269-71.
  50. Sun Y and Yang J. Experimental Study of the Effect of Astragalus Membranaceus against Herpes Simplex Virus Type 1. Di Jun Yi Da Xue Xue Bao 2004; 24: 57-8.
  51. Cheng HY, Lin LT, Huang HH, Yang CM and Lin CC. Yin Chen Hao Tang, a Chinese Prescription, Inhibits Both Herpes Simplex Virus Type-1 and Type-2 Infections in Vitro. Antiviral Res. 2008; 77(1): 14-9.
  52. Serkedjieva J and Ivancheva S. Antiherpes Virus Activity of Extracts from the Medicinal Plant Geranium Sanguineum L. J. Ethnopharmacol. 1999; 64(1): 59-68.